Publications

Building Blocks of Understanding: Constructing a Reverse Genetics Platform for studying determinants of SARS-CoV-2 replication

Marco Olguin-Nava, Patrick Bohn, Thomas Hennig, Charlene Börtlein, Anne-Sophie Gribling-Burrer, Nora Schmidt, Neva Caliskan, Lars Dölken, Mathias Munschauer, Redmond P. Smyth

Cold Spring Harbor Laboratory · 06 Feb 2024 · doi:10.1101/2024.02.05.578560

SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells

Jens Aydin, Alexander Gabel, Sebastian Zielinski, Sabina Ganskih, Nora Schmidt, Christina R Hartigan, Monica Schenone, Steven A Carr, Mathias Munschauer

Nucleic Acids Research · 28 Jan 2024 · doi:10.1093/nar/gkae038

Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts

Barbara Trifault, Victoria Mamontova, Giacomo Cossa, Sabina Ganskih, Yuanjie Wei, ..., Peter Gallant, Elmar Wolf, Dorthe H Larsen, Mathias Munschauer, Kaspar Burger

Nucleic Acids Research · 15 Jan 2024 · doi:10.1093/nar/gkae022

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9

Nora Schmidt, Sabina Ganskih, Yuanjie Wei, Alexander Gabel, Sebastian Zielinski, ..., Andreas Pichlmair, Steven A. Carr, Petr Chlanda, Florian Erhard, Mathias Munschauer

Cell · 01 Oct 2023 · doi:10.1016/j.cell.2023.09.002

Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency

David C. Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M. Merkel

OpenNano · 01 Jul 2023 · doi:10.1016/j.onano.2023.100161

Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness

Caleb A. Lareau, Yajie Yin, Jacob C. Gutierrez, Ryan S. Dhindsa, Anne-Sophie Gribling-Burrer, ..., William J. Greenleaf, Anshul Kundaje, Mathias Munschauer, Leif S. Ludwig, Ansuman T. Satpathy

Cold Spring Harbor Laboratory · 23 Apr 2023 · doi:10.1101/2023.04.23.537997

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1

Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Nan Liu, Taiju Utsugisawa, ..., Stuart H. Orkin, Aviv Regev, Timothy L. McCavit, Hitoshi Kanno, Vijay G. Sankaran

Blood · 21 Apr 2022 · doi:10.1182/blood.2021013753

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, ..., Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, Leo Nicolai

Nature Communications · 23 Feb 2022 · doi:10.1038/s41467-022-28508-0

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral
<i>UL4</i>
/
<i>UL5</i>
Transcripts

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 / UL5 Transcripts

Ana Cristina Gonzalez-Perez, Markus Stempel, Emanuel Wyler, Christian Urban, Antonio Piras, ..., Andreas Pichlmair, Lars Dölken, Mathias Munschauer, Florian Erhard, Melanie M. Brinkmann

mBio · 29 Jun 2021 · doi:10.1128/mbio.02683-20

Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen

Nora Schmidt, Mathias Munschauer

BIOspektrum · 01 Jun 2021 · doi:10.1007/s12268-021-1587-3

The SARS-CoV-2 RNA–protein interactome in infected human cells

Nora Schmidt, Caleb A. Lareau, Hasmik Keshishian, Sabina Ganskih, Cornelius Schneider, ..., Utz Fischer, Jörg Vogel, Steven A. Carr, Jochen Bodem, Mathias Munschauer

Nature Microbiology · 21 Dec 2020 · doi:10.1038/s41564-020-00846-z

The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer

Minakshi Gandhi, Matthias Groß, Jessica M. Holler, Si’Ana A. Coggins, Nitin Patil, ..., Monica Schenone, Christina R. Hartigan, Heike Allgayer, Baek Kim, Sven Diederichs

Nature Communications · 25 Jun 2020 · doi:10.1038/s41467-020-17007-9

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Anindita Basak, Mathias Munschauer, Caleb A. Lareau, Kara E. Montbleau, Jacob C. Ulirsch, ..., Steven A. Carr, Jane-Jane Chen, Stuart H. Orkin, Eric S. Lander, Vijay G. Sankaran

Nature Genetics · 20 Jan 2020 · doi:10.1038/s41588-019-0568-7

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, ..., Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky, Klaus Rajewsky

Genes & Development · 07 Nov 2019 · doi:10.1101/gad.330134.119

New insights into the cellular temporal response to proteostatic stress

Justin Rendleman, Zhe Cheng, Shuvadeep Maity, Nicolai Kastelic, Mathias Munschauer, ..., Markus Landthaler, Lindsay Freeberg, Scott Kuersten, Hyungwon Choi, Christine Vogel

eLife · 12 Oct 2018 · doi:10.7554/eLife.39054

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

Mathias Munschauer, Celina T. Nguyen, Klara Sirokman, Christina R. Hartigan, Larson Hogstrom, ..., Jenny Chen, Monica Schenone, Mitchell Guttman, Steven A. Carr, Eric S. Lander

Nature · 27 Aug 2018 · doi:10.1038/s41586-018-0453-z

Nuclear lnc
<scp>RNA</scp>
stabilization in the host response to bacterial infection

Nuclear lnc RNA stabilization in the host response to bacterial infection

Mathias Munschauer, Jörg Vogel

The EMBO Journal · 22 Jun 2018 · doi:10.15252/embj.201899875

Quantifying multi-layered expression regulation in response to stress of the endoplasmic reticulum

Justin Rendleman, Zhe Cheng, Shuvadeep Maity, Nicolai Kastelic, Mathias Munschauer, ..., Markus Landthaler, Lindsay Freeberg, Scott Kuersten, Hyungwon Choi, Christine Vogel

Cold Spring Harbor Laboratory · 25 Apr 2018 · doi:10.1101/308379

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

Rajiv K. Khajuria, Mathias Munschauer, Jacob C. Ulirsch, Claudia Fiorini, Leif S. Ludwig, ..., Hanna T. Gazda, Winston Y. Lee, Vikram G. Panse, Steven A. Carr, Vijay G. Sankaran

Cell · 01 Mar 2018 · doi:10.1016/j.cell.2018.02.036

Developmentally‐faithful and effective human erythropoiesis in immunodeficient and <i>Kit</i> mutant mice

Developmentally‐faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice

Claudia Fiorini, Nour J. Abdulhay, Sean K. McFarland, Mathias Munschauer, Jacob C. Ulirsch, Roberto Chiarle, Vijay G. Sankaran

American Journal of Hematology · 19 Jul 2017 · doi:10.1002/ajh.24805

Systematic mapping of functional enhancer–promoter connections with CRISPR interference

Charles P. Fulco, Mathias Munschauer, Rockwell Anyoha, Glen Munson, Sharon R. Grossman, Elizabeth M. Perez, Michael Kane, Brian Cleary, Eric S. Lander, Jesse M. Engreitz

Science · 11 Nov 2016 · doi:10.1126/science.aag2445

Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins

Rebecca Bish, Nerea Cuevas-Polo, Zhe Cheng, Dolores Hambardzumyan, Mathias Munschauer, Markus Landthaler, Christine Vogel

Biomolecules · 15 Jul 2015 · doi:10.3390/biom5031441

High-Resolution Profiling of Protein-RNA Interactions

Mathias Munschauer

Springer Theses · 01 Jan 2015 · doi:10.1007/978-3-319-16253-9

MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs

Lea H. Gregersen, Markus Schueler, Mathias Munschauer, Guido Mastrobuoni, Wei Chen, Stefan Kempa, Christoph Dieterich, Markus Landthaler

Molecular Cell · 01 May 2014 · doi:10.1016/j.molcel.2014.03.017

High-resolution profiling of protein occupancy on polyadenylated RNA transcripts

Mathias Munschauer, Markus Schueler, Christoph Dieterich, Markus Landthaler

Methods · 01 Feb 2014 · doi:10.1016/j.ymeth.2013.09.017

Differential protein occupancy profiling of the mRNA transcriptome

Markus Schueler, Mathias Munschauer, Lea Haarup Gregersen, Ana Finzel, Alexander Loewer, Wei Chen, Markus Landthaler, Christoph Dieterich

Genome Biology · 01 Jan 2014 · doi:10.1186/gb-2014-15-1-r15

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation

Robin Graf, Mathias Munschauer, Guido Mastrobuoni, Florian Mayr, Udo Heinemann, Stefan Kempa, Nikolaus Rajewsky, Markus Landthaler

RNA Biology · 01 Jul 2013 · doi:10.4161/rna.25194

Circular RNAs are a large class of animal RNAs with regulatory potency

Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti, Francesca Torti, Janna Krueger, ..., Ulrike Ziebold, Markus Landthaler, Christine Kocks, Ferdinand le Noble, Nikolaus Rajewsky

Nature · 27 Feb 2013 · doi:10.1038/nature11928

FMRP targets distinct mRNA sequence elements to regulate protein expression

Manuel Ascano, Neelanjan Mukherjee, Pradeep Bandaru, Jason B. Miller, Jeffrey D. Nusbaum, ..., Scott Dewell, Markus Hafner, Zev Williams, Uwe Ohler, Thomas Tuschl

Nature · 01 Dec 2012 · doi:10.1038/nature11737

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

Alexander G. Baltz, Mathias Munschauer, Björn Schwanhäusser, Alexandra Vasile, Yasuhiro Murakawa, ..., Emanuel Wyler, Richard Bonneau, Matthias Selbach, Christoph Dieterich, Markus Landthaler

Molecular Cell · 01 Jun 2012 · doi:10.1016/j.molcel.2012.05.021

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins

Markus Hafner, Markus Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, ..., Alexander Ulrich, Greg S. Wardle, Scott Dewell, Mihaela Zavolan, Thomas Tuschl

Journal of Visualized Experiments · 02 Jul 2010 · doi:10.3791/2034

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

Markus Hafner, Markus Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, ..., Alexander Ulrich, Greg S. Wardle, Scott Dewell, Mihaela Zavolan, Thomas Tuschl

Cell · 01 Apr 2010 · doi:10.1016/j.cell.2010.03.009